Infertility and Polycystic ovary syndrome
Primary amenorrhea is the failure of menses to occur by age 16 years, in the presence of normal growth and secondary sexual characteristics. Anovulation is a not a disease but a sign, in much the same way that polycystic ovaries are the manifestation of a much larger disease process. Infertility affects approximately 13-14% of reproductive-aged couples. It is defined as the inability to conceive after 1 year of properly timed, unprotected intercourse. About 1-2% of women with improperly managed an ovulatory bleeding eventually may develop endometrial cancer. PCOS can result from abnormal function of the hypothalamic-pituitary-ovarian (HPO) axis. A woman is diagnosed with polycystic ovaries, if she has 12 or more follicles in at least 1 ovary.